Soluble fusion molecules with binding specificity for cell adhes

Details Soluble fusion molecules with binding specificity for cell adhes Soluble fusion molecules with binding specificity for cell adhes

1991-12-20

1999-01-19

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241361, 4241301, 435 697, 530350, 5303873, C07K 1900, A61K 31395, A61K 4500

Patent

active

058611517

ABSTRACT:
Soluble fusion molecules were prepared which contained a CD11a/CD18 specific binding region operatively linked to an immunoglobulin constant region. These molecules particularly include extracellular portions of adhesion molecules such as ICAM-1 and ICAM-2 attached to IgG constant regions.
The fusion molecules described are utilized as costimulatory agents for the activation of T cells and in methods for increasing CD4.sup.+ T cell proliferative response and IL-2 induction.

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