Soluble, functional apoptotic protease-activating factor 1...

Details Soluble, functional apoptotic protease-activating factor 1... Soluble, functional apoptotic protease-activating factor 1...

2005-01-28

2008-10-07

Carlson, Karen Cochrane (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S440000, C530S350000, C530S300000

Reexamination Certificate

active

07432093

ABSTRACT:
The structure of a soluble, functional fragment of human Apaf-1 protein having ADP bound thereto is disclosed. The invention includes such soluble, functional fragments of human Apaf-1 and other metazoan Apaf-1 homologs. Also included in the invention are methods of making such fragments and methods of using them, for example in screening methods to identify adenine nucleotide analogs and other compounds useful for alleviating or preventing disease conditions associated with inappropriate regulation of apoptosis.

REFERENCES:
patent: 6403765 (2002-06-01), Alnemri
patent: WO 9855615 (1998-12-01), None
patent: WO 0100827 (2001-01-01), None
Alnemri et al. “Truncated APAF-1 and methods of use,” SEQ ID No. 1 alignment result 6, Database: Issued—Patents—AA, Jun. 16, 1998.
Acehan et al., 2002, Mol. Cell 9:423-432.
Benedict, 2000, J. Biol. Chem. 275:8461-8468.
Cecconi et al., 1998, Cell 94:727-737.
Collaborative Computational Project, 1994, Acta Crystallogr. D50:760-763.
Dangl et al., 2001, Nature 411:826-833.
Danial et al., 2004, Cell 116:205-219.
Fearnhead et al., 1998, Proc. Natl. Acad. Sci. 95:13664-1366.
Gai et al., 2004, Cell 119:47-60.
Gai et al., 2004, J. Biol. Chem. 279:38952-38959.
Genini et al., 2000, J. Biol. Chem. 275:29-34.
Green et al., 2002, Cancer Cell 1:19-30.
Hanahan et al., 2000, Cell 100:57-70.
Holm et al., 1993, J. Mol. Biol. 233:123-138.
Horvitz, 2003, ChemBioChem 4:697-711.
Hu et al., 1998, J. Biol. Chem. 273:33489-33494.
Hu et al., 1999, EMBO J. 18:3586-3595.
Inohara et al., 1999, J. Biol. Chem. 274:14560-14567.
Inohara et al., 2001, Oncogene 20:6473-6481.
Jaroszewski et al., 2000, Proteins 39:197-203.
Jiang et al., 2000, J. Biol. Chem. 275:31199-31203.
Jones et al., 1991, Acta Crystallogr. A47:110-119.
Juliusson et al., 1996, J. Clin. Oncol. 14:2160-2166.
Kanuka et al., 1999, Mol. Cell 4:757-769.
Kaufmann et al., 1996, Mech. Dev. 57:3-20.
Kawasaki et al., 1993, Blood 81:597-601.
Lenzen et al., 1998, Cell 94:525-536.
Leoni et al., 1998, Proc. Natl. Acad. Sci. USA 95:9567-9571.
Li et al., 1997, Cell 91:479-489.
Lupas et al., 2002, Curr. Opin. Struct. Biol. 12:746-753.
Neuwald et al., 1999, Genome Res. 9:27-43.
Ogura et al., 2001, J. Biol. Chem. 276:4812-4818.
Otwinowski et al., 1997, Methods Enzymol. 276:307-326.
Poyet et al., 2001, J. Biol. Chem. 276:28309-28313.
Qin et al., 1999, Nature 399:549-557.
Riedl et al., 2004, Nature Rev. Mol. Cell. Biol. 5:897-907.
Rodriguez et al., 1999, Genes Dev. 13:3179-3184.
Rodriguez et al., 1999, Nat. Cell Biol. 1:272-279.
Saleh et al., 1999, J. Biol. Chem. 274:17941-17945.
Soengas et al., 1999, Science 284:156-159.
Soengas et al., 2001, Nature 409:207-211.
Srinivasula et al., 1998, Mol. Cell 1:949-957.
Terwilliger et al., 1999, Acta Crystallogr. D55:849-861.
Vaughn et al., 1999, J. Mol. Biol. 293:439-447.
Wang, 2004, J. Struct. Biol. 148:259-267.
Yoshida et al., 1998, Cell 94:739-750.
Yuan et al., 2000, Nature 407:802-809.
Yuan et al., 1992, Development 116:309-320.
Zhang et al., 2000, Mol. Cell 6:1473-1484.
Zhou et al., 1999, Mol. Cell 4:745-755.
Zhou et al., 1999, Proc. Natl. Acad. Sci. USA 96(20):11265-11270.
Zou et al., 1999, J. Boil. Chem. 274:11549-11556.
Zou et al., 1997, Cell 90:405-413.

Affiliated with

Also associated with

Rating

Soluble, functional apoptotic protease-activating factor 1... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Soluble, functional apoptotic protease-activating factor 1..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Soluble, functional apoptotic protease-activating factor 1... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4005958