Package making
Patent
1993-11-12
1995-06-06
Knode, Marian C.
Package making
4352401, C12N 500
Patent
active
054222648
ABSTRACT:
A method for growing epithelial cells in vitro using soluble proteins secreted by 804G rat bladder carcinoma cells. These proteins are able to stimulate cell attachment and hemidesmosome formation in cells grown in contact with the proteins. The purification of these proteins from 804G culture supernatant is greatly facilitated by culturing the cells under low serum conditions.
REFERENCES:
patent: 5273900 (1993-12-01), Boyce
Hormia, et al. "The Distribution of Integrin .alpha..sub.6 .beta..sub.4 in Keratinocytes is Modulated by Rat Carcinoma Cells", International Association for Dental Research, Feb. 1993, Abstract, 1 page.
Jones, et al. ".alpha..sub.6 .beta..sub.4 Integrins: Their Role in the Assembly of the Hemidesmosome (HD) and in Signal Transduction", J. Cell. Biochem., Supplement 16F: Apr., 1992.
Langhofer, et al. "Matrix Signals Transduced by the .alpha..sub.6 .beta..sub.4 Integrin Complex", Mol. Biol. Cell., 3, Supplement: 95a, Sep., 1992.
Riddelle, et al. "Substrate Attachment is Necessary for the Expression of Hemidesmosomal Proteins in Cultured Cells", Mol. Biol. Cell., 3, Supplement: 70a, 1992.
Riddelle, et al., "Characterization of a Novel Cell-Substratum Attachment Device in Cultured Epithelial Cells", J. Cell. Biol., 109: 201a, 1989.
Riddelle, et al. "Dynamic Aspects of Hemidesmosomes in the Novel Epithelial Cell Line, 804G", J. Cell. Biol., 115: 41a, 1991.
Hopkinson, et al. "Expression of Hemidesmosomal Plaque Components", J. Cell. Biol., 111: 408a, 1990.
Riddelle, et al. "Hemidesmosomes in Cultered Cells", J. Cell. Biol., 111: 408a, 1990.
Kurpakus, et al. "Integrins in the Hemidesmosome", J. Cell. Biol., 111: 402a, 1990.
Schwartz, et al. "Desmosomes and Hemidesmosomes: Constitutive Molecular Components", Annu. Rev. Cell. Biol., 6: 461-91, 1990.
Jones, et al. "Intermediate Filament-Plasma Membrane Interactions", Curr. Opin. Cell Biology, 3: 127-132, 1991.
Chapman, et al., "Abnormal Expression of Hemidesmosome-Like Structures by Junctional Epidermolysis Bullosa Keratinocytes in Vitro", British Journal of Dermatology, 123: 137-144, 1990.
Giudice, et al., "Identification of Collagen Domains within the Bullous Pemphigoid Autoantigen, BP180", J. Clin. Invest., 87: 734-738, 1991.
Hieda, et al., "Idenficiation of a New Hemidesmosomal Protein, HD1: A Major, High Molecular Mass Component of Isolated Hemidesmosomes", The Journal of Cell Biology, 116: 1497-1506, 1992.
Izumi, et al. "In Vitro Induction of Ornithine Decarboxylase in Urinary Bladder Carcinoma Cells", Cancer Research, 41: 405-409, 1981.
Kurpakus, et al. "Surface Relocation of .alpha..sub.6 .beta..sub.4 Integrins and Assembly of Hemidesmosomes in an In Vitro Model of Wound Healing", The Journal of Cell Biology, 115:1737-1750, 1991.
Staehelin, "Structure and Function of Intercellular Junctions", Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colo.: 191-283.
Stepp, et al., ".alpha..sub.6 .beta..sub.4 Integrin Heterodimer is a Component of Hemidesmosomes", Proc. Natl. Acad. Sci. USA, 87: 8970-8974, 1990.
Sonnenberg, et al., "Integrin .alpha..sub.6 /.beta..sub.4 Complex is Located in Hemidesmosomes, Suggesting a Major Role in Epidermal Cell-Basement Membrane Adhesion", The Journal of Cell Biology, 113: 907-917, 1991.
Hopkinson, et al., "Cytoplasmic Domain of the 180-kD Bullous Pemphigoid Antigen, A Hemidesmosomal Component: Molecular and Cell Biologic Characterization", J. Invest. Dermatol.: 264-270, 1992.
Langhofer, et al., "The Matrix Secreted by 804G Cells Contains Laminin-Related Components that Participate in Hemidesmosome assembly in Vitro", Journal of Cell Science, 105: 753-764, 1993.
Riddelle, et al., "Hemidesmosomes in the Epithelial Cell Line 804G: Their Fate During Would Closure, Mitosis and Drug Induced Reorganization of the Cytoskeleton", Journal of Cell Science, 103: 475-490, 1992.
Riddelle, et al., "Formation of Hemidesmosomes in Vitro by a Transformed Rat Bladder Cell Line", Journal of Cell Biology, 112: 159-168, 1991.
Hormia Marketta
Quaranta Vito
Desmos, Inc.
Knode Marian C.
Larson Kristin
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