Soluble ectodomain fragments of MET and uses thereof

Details Soluble ectodomain fragments of MET and uses thereof Soluble ectodomain fragments of MET and uses thereof

2004-09-15

2010-06-22

Rao, Manjunath N (Department: 1656)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S300000, C530S350000

Reexamination Certificate

active

07741051

ABSTRACT:
The invention relates a fragment derived from the MET ectodomain which the inventors have found is capable, in monomer form, of binding to HGF/SF either in the presence or absence of heparin. The availability of soluble, monomeric forms of the MET receptor enabled studies of its solution properties and HGF/SF binding and provides an assay comprising the steps of (a) providing a MET ectodomain fragment; (b) providing an agent; and (c) determining the extent to which the agent interacts with said fragment.

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