Soluble cyclic analogues of β amyloid peptide

Details Soluble cyclic analogues of β amyloid peptide Soluble cyclic analogues of β amyloid peptide

2001-12-21

2008-03-11

Chernyshev, Olga N. (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C514S009100, C514S012200, C435S007100, C435S007920, C435S007500, C436S503000, C436S501000, C436S547000, C436S544000, C436S545000, C424S001570, C424S001690, C424S193100

Reexamination Certificate

active

07342091

ABSTRACT:
The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use.

REFERENCES:
patent: 5854204 (1998-12-01), Findeis et al.
patent: 197 25 619 (1998-12-01), None
patent: WO 00/38618 (2000-07-01), None
patent: WO 01/34631 (2001-05-01), None
Findeis, et al., “ Modified-Peptide Inhibitors of Amyloid β-Peptide Polymerization,” Biochemistry, vol. 38, No. 21, pp. 6791-6800, (1999).
Harkany, et al., “Neuroprotective Approaches in Experimental Models of β-Amyloid Neurotoxicity: Relevance to Alzheimer's Disease,” Prog. Neuro-Psychopharmacol. & Biol. Psychiat., vol. 23, pp. 963-1008, (1999).
Hilbich, et al., “Substitutions of Hydrophobic Amino Acids Reduce the Amyloidogenicity of Alzheimer's Disease βA4 Peptides,” J. Mol. Biol., No. 228, pp. 460-473 (1992).

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