Soluble collagen sponge

Details Soluble collagen sponge Soluble collagen sponge

1986-06-20

1988-12-06

Morris, Theodore

Compositions: coating or plastic

Coating or plastic compositions

Pore forming

106155, 106161, 604368, 604369, 514947, 514950, C08L 8906, A61F 1316

Patent

active

047894016

ABSTRACT:
The invention concerns a collagen sponge which has a denaturation temperature of at least 37.degree. C., is not cross-linked and in one of its two embodiments forms an optically clear solution in aqueous medium. As compared with the collagen sponges previously known, it is particularly suitable as support material for pharmaceutical and cosmetic active substances since it has a higher denaturation temperature than the latter and dissolves again in contact with body fluid. The collagen sponge of the invention is prepared from an optically clear collagen solution by precipitation with neutral salts, dissolving and reprecipitation and then subjecting the collagen to freeze-drying without removal of the precipitation salt. Acid-swollen collagens and/or cellulose or cellulose derivatives can also be added to the solution, whereby the physical properties of the collagen sponge can be affected.

REFERENCES:
patent: 3157524 (1964-11-01), Artandi
patent: 4279812 (1981-07-01), Cioca
patent: 4295894 (1981-10-01), Cioca et al.
patent: 4412947 (1983-11-01), Cioca
Das Leder, 12th edition, No. 9, Sep. 1961, pp. 213-222+translation of pp. 213 and 214.
Das Leder, 29th vol., No. 3, Mar. 1978, pp. 33-41 plus translation of pp. 36 and 40.
Kollagen by Verlag Theodore Steinkopf, Dresden 1966, pp. 82, 119, 120 & 121, cover sheet and translation of relevant portions.

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