Soluble and stabilized trimeric form of gp41 polypeptides

Details Soluble and stabilized trimeric form of gp41 polypeptides Soluble and stabilized trimeric form of gp41 polypeptides

2011-04-05

2011-04-05

Parkin, Jeffrey S. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S208100

Reexamination Certificate

active

07919100

ABSTRACT:
The present invention concerns a modified polypeptide containing at least an immunodominant region and the connecting loop between N- and C-helices of gp41 ectodomain of HIV-1, wherein the connecting loop includes at least a linker fragment having: —a size convenient for keeping the native conformation of the interaction between N- and C-helices, and —an hydrophily sufficient to provide a soluble and stable trimeric form to said modified polypeptide.

REFERENCES:
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patent: WO 99/25377 (1999-05-01), None
patent: WO 02/34909 (2002-05-01), None
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