Soluble analogs of probucol

Details Soluble analogs of probucol Soluble analogs of probucol

1992-04-30

1993-11-16

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514712, 560138, 562590, 562595, 568 52, A61K 31225, C07C 69017, C07C 6708

Patent

active

052624390

ABSTRACT:
The invention provides a class of water-soluble probucol derivatives having one or more ester groups replacing the phenyl hydroxyl groups of the probucol molecule. Some derivatives have polar or charged functionalities such as carboxylic acid groups, amino groups, aldehyde groups and amide groups located on the ester groups. Some of these compounds are spontaneously hydrolyzable in typical biological milieus. The present invention also provides method of treating an animal with probucol by administering a water-soluble probucol prodrug to the animal.

REFERENCES:
patent: 3576883 (1971-04-01), Neuworth et al.
patent: 3862332 (1975-01-01), Barnhart et al.
patent: 4719237 (1988-01-01), McCaughan
patent: 4985465 (1991-01-01), Hendler
Daniel Steinberg, (1991), Circulation 84:1420-1425.

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