Soluble alkyl[5-[amino (phenyl)methyl]-1H-benzimidazol-2-yl] car

Details Soluble alkyl[5-[amino (phenyl)methyl]-1H-benzimidazol-2-yl] car Soluble alkyl[5-[amino (phenyl)methyl]-1H-benzimidazol-2-yl] car

1992-05-12

1994-01-11

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483064, A61K 31415, C08D23532

Patent

active

052781810

ABSTRACT:
Soluble alkyl [5-(amino (phenyl)methyl)-2H-benzimidazol-2-yl]carbamates, their enantiomorphic forms, and acid addition salts thereof are well absorbed and possess curative anthelmintic activity, especially against filarial worms, when administered orally or parenterally. Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating helminth infections in mammals are also disclosed, together with methods of synthesis.

REFERENCES:
patent: 3657267 (1972-04-01), Van Gelder
patent: 4435418 (1984-03-01), Chow
patent: 4826862 (1989-05-01), Raeymaekers et al.
"The Synthesis and Chemistry of Certain Anthelmintic Benzimidazoles", by L. B. Townsend & D. S. Wise, in Parasitology Today, vol. 6, No. 4, 1990.

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