Soluble active hepatitis C virus protease

Details Soluble active hepatitis C virus protease Soluble active hepatitis C virus protease

1995-05-12

1998-12-01

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 697, 435 691, 4353201, 4352523, 4351723, 530300, 536 232, 536 2372, C12N 950

Patent

active

058437525

ABSTRACT:
Soluble covalent HCV NS3-NS4A complexes comprising the catalytic domain of native HICV NS3 protease fused to an HCV NS4A cofactor, wherein the cofactor has been modified to prevent cleavage by the HCV NS3 protease.

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Failla et al. J Virol (1994) 68:3753-3760 "Both NS3 and NS4A are Required for Proteolytic Processing of Hepatitis C Virus Nonstructural Proteins" Novagen Catalog (1991).
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Tanji et al., J. Virology 69: 1575-1581 (1995).

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