Solubilizing of metronidazole

Details Solubilizing of metronidazole Solubilizing of metronidazole

2011-07-19

2011-07-19

Anderson, James (Department: 1629)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S356000, C424S273100, C260S66500B

Reexamination Certificate

active

07981916

ABSTRACT:
Metronidazole is solubilized in an aqueous phase, by mixing same with niacinamide and at least two glycolic cosolvents; the resulting solutions and pharmaceutical compositions comprised thereof are useful for the treatment of dermatological conditions/afflictions, notably rosacea.

REFERENCES:
patent: 4032645 (1977-06-01), Chien et al.
patent: 6444647 (2002-09-01), Robinson et al.
patent: 6517847 (2003-02-01), Dow et al.
patent: 2004/0242463 (2004-12-01), Kung et al.
patent: 58059913 (2003-04-01), None
patent: WO 02/06349 (2002-01-01), None
patent: WO 02/094179 (2002-11-01), None
patent: WO 03/057135 (2003-07-01), None
Chien, “Solubilization of Metronidazole by Water-Miscible Multi-Cosolvents and Water-Soluble Vitamins”, Journal of Parenteral Science and Technology, Jan. 1984, pp. 32-36, vol. 38, No. 1, Flagyl, Scarle Pharmaceuticals, Inc. IL.
International Search Report corresponding to PCT/FR 2006/001367, issued Dec. 1, 2006, 4 pages.

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