Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...
Reexamination Certificate
1999-01-29
2001-04-10
Pezzzuto, Helen L. (Department: 1713)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Polymers from only ethylenic monomers or processes of...
C526S274000, C526S277000, C526S310000, C526S312000, C526S328000, C526S328500
Reexamination Certificate
active
06214957
ABSTRACT:
FIELD OF ART
The present invention relates to solubilizers, emulsifiers and dispersing agents having a function of solubilizing, emulsifying or dispersing various compounds or materials, and which can be used in the fields of washing agents, coatings, chemical products, and pharmaceuticals.
BACKGROUND OF ART
In various fields of art, various surfactants are widely used as washing agents, solubilizers, emulsifiers and dispersing agents. Substances to be solubilized, emulsified or dispersed may include dirt to be washed off, as well as oils and fats, agents and chemical products in the field of pharmaceuticals.
As high-molecular surfactants has been known polyoxyethylene monostearate, polyoxyethylene monooleate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan trioleate, polyoxyethylene monolauryl ether, polyvinyl pyrrolidone, carboxymethyl cellulose, hydroxypropyl cellulose, gelatine and gum arabic. However, when such high-molecular surfactants are used as a skin washing agent, these surfactants cannot always give a good effect on skin. Particularly, such surfactants cannot give a moistness feeling on skin.
In the pharmaceutical field, the various high-molecular surfactants are known to be useful as a suspending agent or an emulsifying agent (Japanese Pharmacopoeia, 13th edition, Hirokawa Shoten, Tokyo, 1996).
Further, it is known that albumin, gelatine, starch or agarose, which are surfactants derived from natural organisms, can be used as a drug carrier for improving apparent solubility of a drug (Iyakuhin no Kaihatsu (development of pharmaceuticals), 13th edition, Yakubutsusoutatsuhou (drug derivery), edited by Hitoshi SEZAKI, Torakawa Shoten (1995), p216-331). It is also known that a block copolymer of polyethylene glycol-poly amino acid, a surfactant not derived from natural organisms, can be used as a drug carrier (Japanese Laid-open Patent Application No.1994-107565).
The safety of the above-mentioned surfactants derived from natural organisms is lowered by contamination. The surfactants not derived from natural organisms do not exhibit sufficient solubilizing, emulsifying or dispersing ability depending on the nature of substances to be solubilized, emulsified or dispersed.
It is known that a homopolymer of 2-methacryloyloxyethyl phosphorylcholine and a copolymer of 2-methacryloyloxyethyl phosphorylcholine and hydrophilic and/or hydrophobic monomers exhibit moisture retaining effect and anti-chapping effect on skin, and can be used for cosmetics (Japanese Laid-open Patent Application Nos.93-70321, 94-157269, 94-157270 and 94-157271). However, it is not known that these polymers exhibit solubilizing, emulsifying and dispersing effect.
DISCLOSURE OF THE INVENTION
The object of the present invention is to provide a solubilizer, an emulsifier, or a dispersing agent that can give moistness feeling to the skin when used as a skin washing agent. Another object of the present invention is to provide a solubilizer, an emulsifier or a dispersing agent having the character of elevating the concentration of a material to be solubilized, emulsified or dispersed in solvents including water as compared with the case where the material is employed alone, or elevating the apparent concentration of a material to be emulsified or dispersed in solvents by increasing homogeneity of the emulsion or dispersion.
The present inventors made extensive studies in the light of the above problems, and found out that a polymer of a hydrophilic monomer, and a polymer produced by polymerizing a monomer composition containing a specific hydrophilic monomer and hydrophobic monomer, can be an excellent solubilizer, emulsifier and dispersing agent, to accomplish the present invention.
That is, according to the present invention, there is provided a solubilizer, an emulsifier or a dispersing agent comprising as an effective ingredient a polymer produced by polymerizing a monomer composition containing a hydrophilic monomer (a) having in a side chain thereof a group represented by the formula (1):
wherein R
1
, R
2
and R
3
denote a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and are the same or different groups.
According to the present invention, there is further provided a solubilizer, an emulsifier or a dispersing agent comprising as an effective ingredient a polymer produced by polymerizing a monomer composition consisting of, as a hydrophilic monomer (a), 100 to 20 wt % of 2-(methacryloyloxy)ethyl-2′-(alkyl-substituted or non-substituted ammonio)ethyl phosphate represented by the formula (2):
(wherein R
1
, R
2
and R
3
denote a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and are the same or different groups) and, as a hydrophobic monomer (b), 0 to 80 wt % of (meth)acrylate represented by the formula (3):
(wherein R
4
denotes a hydrogen atom or a methyl group, and R
5
denotes an alkyl group having 4 to 8 carbon atoms).
REFERENCES:
patent: 2-172529 (1990-07-01), None
patent: 3-76762 (1991-04-01), None
patent: 6-41157 (1994-02-01), None
patent: 7-68147 (1995-03-01), None
patent: 3-64373 (1996-12-01), None
patent: 94/14897 (1994-07-01), None
Ishihara et al., Biomaterials, 16 (Jul. 1996), 873-879.*
Sugiyama et al., Macromol. Chem. Phys., 196, 1907-1916 (Jul. 1995).
Ishihara Kazuhiko
Nakabayashi Nobuo
Shiino Daijiro
Waki Kazunori
Darby & Darby
NOF Corporation
Pezzzuto Helen L.
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