Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1991-03-18
1991-12-31
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
540204, A61K 3138, C07D22300
Patent
active
050772821
ABSTRACT:
The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.
REFERENCES:
patent: 4431588 (1984-02-01), Pfaendler
Lee Ving J.
Murdock Keith C.
American Cyanamid Company
Richter Johann
Szatkowski Thomas S.
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