Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1991-03-18
1991-12-31
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514397, 548111, 548336, A61K 31415, C07D40310, C07F 928
Patent
active
050772830
ABSTRACT:
The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, quanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.
REFERENCES:
patent: 4900838 (1990-02-01), Murdock
Lee Ving J.
Murdock Keith C.
American Cyanamid Company
Richter Johann
Szatkowski Thomas S.
LandOfFree
Solubilized imidazole pro-drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Solubilized imidazole pro-drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solubilized imidazole pro-drugs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1510322