Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1986-06-27
1988-05-17
Foelak, Morton
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530395, 530389, 530390, 530391, 530402, 530403, 530405, 514 2, 514 8, 514 56, 424 85, 435811, C07K 1500, A61K 4502, A61K 3702, A61K 3900
Patent
active
047451807
ABSTRACT:
A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is poorly or not at all water-soluble at pH 6-8 without such solubilizing agent, is selectively conjugated to at least one heparin fragment having a terminal 2,5-anhydro-D-mannose residue which has an aldehyde not involved in intramolecular hemiacetal formation.
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Moreland Margaret
Nitecki Danute E.
Cetus Corporation
Draper Garnette D.
Foelak Morton
Halluin Albert P.
Hasak Janet E.
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