Solubilization of proteins for pharmaceutical compositions using

Details Solubilization of proteins for pharmaceutical compositions using Solubilization of proteins for pharmaceutical compositions using

1986-11-14

1990-01-16

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 424 854, 424 856, 424 88, A61K 3702, A61K 4502

Patent

active

048942260

ABSTRACT:
A pharmaceutical composition is prepared wherein a biologically active conjugated protein is dissolved in an aqueous carrier medium in the absence of a solubilizing agent. The unconjugated protein, which is not readily water-soluble at pH 6-8 without such solubilizing agent, is covalently conjugated to polyproline via a flexible spacer arm and exhibits substantial biological activity.

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E. Mozes et al., Antibody Response of Inbred Mouse Strains to Ordered (1974), Tetrapeptides of Tyrosine and Glutamic Acid Attached to Multi, etc., 81:289 (1974).
Morimoto et al., J. Pharm. Dyn., 7, 688-698 (1984).
Tsukada et al., JNCI (1984) 73:721-729.

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