Solubilization of proteins for pharmaceutical compositions using

Details Solubilization of proteins for pharmaceutical compositions using Solubilization of proteins for pharmaceutical compositions using

1988-01-25

1988-08-23

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530351, 424 85, 424 83, A61K 3702, C07K 1300

Patent

active

047661062

ABSTRACT:
A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is not water-soluble or not readily soluble in water at pH 6-8 without such solubilizing agent, is selectively conjugated to a water-soluble polymer selected from polyethylene glycol homopolymers or polyoxyethylated polyols.

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