Solubilization of lactam and chlorhexidine in water

Details Solubilization of lactam and chlorhexidine in water Solubilization of lactam and chlorhexidine in water

1989-10-10

1991-04-16

Lovering, Richard D.

Compositions

Solids with solution or dispersion aids

514635, B01F 320, A61K 31155

Patent

active

050080385

ABSTRACT:
Solubility of chlorhexidine free base and hydrocarbon substituted lactams in water is substantially enhanced by forming an aqueous solution of a complex of chlorhexidine free base and lactam. This is preferably done by dissolving chlorhexidine free base in lactam and then mixing the resulting solution with water. The resulting aqueous solution contains between about 1 and about 25 wt % of a complex of lactam and chlorhexidine with chlorhexidine being present in amounts between about 0.08 and about 0.25 wt % based on lactam. Lactam used is defined by the formula ##STR1## wherein n is an integer having a value of from 1 to 3 and R is a linear alkyl radical containing from 10 to 14 carbon atoms.

REFERENCES:
patent: 4137332 (1979-01-01), Brown et al.
patent: 4584192 (1986-04-01), Dell et al.
patent: 4920145 (1990-04-01), Cho et al.

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