Solubilization of immunotoxins for pharmaceutical compositions u

Details Solubilization of immunotoxins for pharmaceutical compositions u Solubilization of immunotoxins for pharmaceutical compositions u

1987-12-11

1990-04-17

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

514 12, 530350, A61K 3944, A61K 31745

Patent

active

049178881

ABSTRACT:
A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is not water-soluble or not readily soluble in water at pH 6-8 without such solubilizing agent, is selectively conjugated to a water-soluble polymer selected from polyethylene glycol homopolymers or polyoxyethylated polyols.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4310397 (1982-01-01), Kaetsu et al.

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