Solubilization and stabilization of factor VIII complex

Details Solubilization and stabilization of factor VIII complex Solubilization and stabilization of factor VIII complex

1993-04-29

1995-03-21

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530417, 530427, A61K 3702, A61K 3706, C07K 1300, C07K 320

Patent

active

053996704

ABSTRACT:
A process for facilitating the reconstitution of lyophilized Factor VIII complex compositions, and compositions of Factor VIII complex, which are readily reconstituted. The process of the present invention comprises providing a purified Factor VIII complex preparations; adding a stabilization agent comprising arginine; lyophilizing the stabilization agent-Factor VIII complex solutions; and reconstituting the lyophilized stabilization agent-Factor VIII complex by contacting it with solvent for less than one minute.

REFERENCES:
patent: 4623717 (1986-11-01), Fernandes
patent: 4650678 (1987-03-01), Fuhge et al.
patent: 4650858 (1987-03-01), Rasmussen et al.
patent: 4758657 (1988-06-01), Farb et al.
patent: 5110907 (1992-05-01), Kosow et al.

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