Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-10-24
1993-06-01
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530413, 530420, 530424, 530350, 424 858, A61K 3702, A61K 39395
Patent
active
052159639
ABSTRACT:
A procedure for the preparation of the solubilized and purified gastrin releasing peptide receptor, in an active form, from a gastrin releasing peptide receptor source such as Swiss 3T3 fibroblasts.
REFERENCES:
T. W. Moody, D. N. Carney, F. Cuttitta, K. Quattrocchi and J. D. Minna, "High Affinity Receptors for Bombesin/GRP-like Peptides on Human Small Cell Lung Cancer", Life Sciences 37(2): 105-113 (1985).
F. Cuttitta, D. N. Carney, J. Mulshine, T. W. Moody, J. Fedorko, A. Fischler and J. D. Minna, "Bombesin-like Peptides Can Function as Autocrine Growth Factors in Human Small-Cell Lung Cancer", Nature 316: 823-826 (Aug. 29, 1985).
J. Zachary, P. J. Woll and E. Rozengurt, "A Role for Neuropeptides in the Control of Cell Proliferation", Developmental Biology 124: 295-308 (1987).
R. M. Kris, R. Hagan, J. Villines, T. W. Moody and J. Schlessinger, "Identification of Bombesin Receptor on Murine and Human Cells by Cross-linking Experiment", The Journal of Biological Chemistry. 262(23): 11215-11220 (Aug. 15, 1987).
I. Zachary and E. Rozengurt, "Identification of a Receptor for Peptides of the Bombesin Family in Swiss 3T3 Cells by Affinity Cross-linking", The Journal of Biological Chemistry 262(9): 3947-3950 (Mar. 25, 1987).
J. Mazella, J. Chabry, P. Kitabgi and J. P. Vincent, "Solubilization and Characterization of Active Neurotensin Receptors from Mouse Brains", The Journal of Biological Chemistry 263(1): 144-149 (Jan. 5, 1988).
J. D. Minna, F. Cuttitta, J. F. Battey, J. L. Mulshine, I. Linnoila, A. F. Gazdar, J. Trepel and E. A. Sausville, "Gastrin-Releasing Peptide and Other Antocrine Growth Factors in Lung Cancer: Pathogenetic and Treatment Implications", Important Advances in Oncology, J. B. Lippincott Co., Philadelphia (1988).
Feldman Richard I.
Jenson James C.
Larocca Anne
Mann Elaina
Wu James M.
Berlex Laboratories Inc.
Ching Edwin P.
Dow Karen Babyak
Precivale Shelley G.
Springer David B.
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