Solubilization and purification of the active gastrin releasing

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530350, 530412, 435 691, C07K 14705

Patent

active

055918310

ABSTRACT:
A procedure for the preparation of the solubilized and purified gastrin releasing peptide receptor, in an active form, from a gastrin releasing peptide receptor source such as Swiss 3T3 fibroblasts.

REFERENCES:
patent: 4761371 (1988-08-01), Bell
Penella J. Woll, et al. (1988) "[D-Arg.sup.1, D-Phe.sup.5, D-Trp.sup.7,9, Leu.sup.11 ] substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro", Proc. Natl. Acad. Sci. USA, 85:1859-1863.
Steen E. Pedersen, et al. (1985) "Functional Activation of .beta.-Adrenergic Receptors by Thiols in the Presence or Absence of Agonists", The Journal of Biological Chemistry, 260:14150-14157.
Ian Zachary, et al. (1985) "High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells", Proc. Natl. Acad. Sci. USA, 82:7616-7620.
Terry W. Moody, et al. (1985) "High Affinity Receptors for Bombesin/GRP-Like Peptides on Human Small Cell Lung Cancer", Life Sciences, 37:105-113.
Frank Cuttitta, et al. (1985) "Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer", Nature, 316:823-826.
Yutaka Yanagita, et al. (1986) "Solubilization and purification of membrane proteins," Techniques for the Analysis of Membrane Proteins, Chapter 3, eds. C. I. Ragan & R. J. Cherry (London: Chapman and Hall), 61-77.
Sheridan L. Swope, et al. (1987) "Characterization of ligand binding and processing by bombesin receptors in an insulin-secreting cell line", Biochem. J., 247:731-738.
Ian Zachary, et al. (1987) "A Role for Neuropeptides in the Control of Cell Proliferation", Developmental Biology, 124:295-308.
Richard M. Kris, et al. (1987) "Identification of the Bombesin Receptor on Murine and Human Cells by Cross-linking Experiments", The Journal of Biological Chemistry, 262:11215-11220.
Yasuo Masu, et al. (1987) "cDNA cloning of bovine substance-K receptor through oocyte expression system", Nature, 329:836-838.
James B. Fischer, et al. (1988) "The Bombesin Receptor Is Coupled to a Guanine Nucleotide-binding Protein Which Is Insensitive to Pertussis and Cholera Toxins", The Journal of Biological Chemistry, 263:2808-2816.
John D. Minna, et al. (1988) "Gastrin-Releasing Peptide and Other Autocrine Growth Factors in Lung Cancer: Pathogenetic and Treatment Implications," Important Advances in Oncology, Chapter 4, (Philadelphia: J. B. Lippincott Co.), 55-64.
Anders Sundan (1988) "Identification of the Bombesin Receptor by Monoclonal Anti-Idiotypic Antibodies", Symposium on Growth Factors and the Receptors: Genetic Control and Rational Application, held at the 17th Annual Meeting of the UCLA Symposia on Molecular and Cellular Biology, Keystone, Colorado, USA, Jan. 24-30, 1988, J. Cell Bio-chem. Suppl., vol. 0, No. 12, Part A, p. 116.
H. G. Khorana (1988) "Bacteriorhodopsin, a Membrane Protein That Uses Light to Translocate Protons", The Journal of Biological Chemistry, 263:7439-7442.
James Sinnett-Smith, et al. (1988) "Characterization of a Bombesin Receptor on Swiss Mouse 3T3 Cells by Affinity Cross-Linking", Journal of Cellular Biochemistry, 38:237-249.
Jean Mazella, et al. (1988) "Solubilization and Characterization of Active Neuortensin Receptors from Mouse Brain", The Journal of Biological Chemistry, 263:144-149.
Kenneth D. Brown, et al. (1988) "Characterization of the high-affinity receptors on Swiss 3T3 cells which mediate the binding, internalization and degradation of the mitogenic peptide bombesin", Biochem. J., 252:227-235.
Wolfgang Meyerhof, et al. (1988) "Expression and electrophysiological identification of the receptor for bombesin and gastrin-releasing peptide in Xenopus laevis oocytes injected with polyA.sup.+ RNA from rat brain", FEB Letters, 239:109-112.
Wolf, Steven S. et al. (1985) "Receptors for GRP/Bombesin-Like Peptides in the Rat Forebrain", Peptides 6:111-114.
Zachary, Ian, et al. (1987) "Identification of a Receptor for Peptides of the Bombesin Family in Swiss 3T3 Cells by Affinity Cross-linking", The Journal of Biological Chemistry, 262:3947-3950.
Spindel, E. R., et al. (1989) "Expression in Xenopus Oocytes of Functional Bombesin/GRP Receptors Transcribed From A Bacteriophage cDNA Library", 19th Annual Meeting Of The Society For Neuroscience, Oct. 29, Nov. 3, 1989, Society Neuroscience Abstract 15:345.
Gaudino, Giovanni, et al. (date: illegible) "A Tyrosine Protein Kinase Activated by Bombesin in Normal Fibroblasts and Small Cell Carcinomas", Annals New York Academy of Sciences, 293-302.
Gaudino, G., et al. (1988) "Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas", Proc. Natl. Acad. Sci., 85:2166-2170.
Zachary, Ian, et al. (1987) "Inhibition of Bombesin-Induced Mitogenesis by Pertussis Toxin: Dissociation From Phospholipase C Pathway", Biochemical and Biophysical Research Communications, 146:456-463.
Letterio, John J., et al. (1986) "Pertussis Toxin-Sensitive Pathway in the Stimulation of c-myc Expression and DNA Synthesis by Bombesin" Science, 117-119.
Cirillo, Daniela M., et al. (1986) "Receptor for Bombesin with Associated Tyrosine Kinase Activity", Molecular and Cellular Biology, 6:4641-4649.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Solubilization and purification of the active gastrin releasing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Solubilization and purification of the active gastrin releasing , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solubilization and purification of the active gastrin releasing will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1765204

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.