Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1995-05-04
1999-09-28
Venkat, Jyothsna
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
426449, A61F 1302
Patent
active
059584467
ABSTRACT:
The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.
REFERENCES:
patent: 3469308 (1969-09-01), Penneck
patent: 4390520 (1983-06-01), Nagai et al.
patent: 4668232 (1987-05-01), Cordes et al.
patent: 4690683 (1987-09-01), Chien et al.
patent: 4693887 (1987-09-01), Shah
patent: 4814168 (1989-03-01), Sablotsky et al.
patent: 4845081 (1989-07-01), Sloan
patent: 4883669 (1989-11-01), Chien et al.
patent: 4906169 (1990-03-01), Chien et al.
patent: 4911916 (1990-03-01), Cleary
patent: 4931281 (1990-06-01), Kim et al.
patent: 4987893 (1991-01-01), Salamone et al.
patent: 4994267 (1991-02-01), Sablotsky
patent: 5032403 (1991-07-01), Sinreich
patent: 5128138 (1992-07-01), Blank
patent: 5149538 (1992-09-01), Granger et al.
patent: 5154271 (1992-10-01), Otsuka et al.
patent: 5154922 (1992-10-01), Govil et al.
patent: 5230898 (1993-07-01), Horstmann et al.
patent: 5252334 (1993-10-01), Chiang et al.
patent: 5262165 (1993-11-01), Govil et al.
patent: 5300291 (1994-04-01), Sablotsky et al.
patent: 5336210 (1994-08-01), Hidaka et al.
patent: 5393529 (1995-02-01), Hoffmann et al.
patent: 5474783 (1995-12-01), Miranda et al.
Vaughn, "Using Solubility Parameters in Cosmetics Formulation", 36 J. Soc. 319-333 Sep./Oct. 1985.
Pfister et al., "Permeation Enhancers Compatible with Transdermal Drug Delivery Systems Part I: Selection and Formulation Considerations", Medical Device Technology, Sep./Oct. 1990, 48-56.
Sloan et al., "Use of Solubility Parameters of Drug and Vehicle to Predict Flux Through Skin", 87 The Journal of Investigative Dermatology, Aug. 1986, pp. 244-252.
Ulman et al., "Drug Permeability of Modified Silicone Polymers", Journal of Controlled Release, 10 (1989) pp. 273-281.
(Abstract) "Development And Characterization of Pseudolatex Based Transdermal Drug Delivery System of Diclofenac", vol. 17, No. 8, pp. 1041-1058, May 1991.
Yu et al., "Transdermal Dual-Controlled Delivery of Testosterone And Estradiol: (1) Impact of System Design", Drug Devel. Indust. Pharm. 17(14): 1883-1904 (1991).
Lichtenberger et al. "Polymer Films From Aqueous Latex Dispersions As Carriers For Transdermal Delivery of Lipophilic Drugs", Proceed. Intern. Symp. Control. Rel Bioact. Mater., 15, (1988) pp. 147-150.
Pfister & Hseih, "Permeation Enhancers Compatible With Transdermal Drug Delivery Systems Part II: System Design Considerations", Medical Device Technology, pp. 54-60, Oct. 1990.
Peck et al. "Aqueous Dispersions of Water-Soluble and Water-Insoluble Cellulosic Polymers As Vehicles For Topical Drug Delivery", Proceed. Intern. Symp. Control. Rel Bioact., 15, No. 90 (1988) pp. 149-150.
Miranda Jesus
Sablotsky Steven
Noven Pharmaceuticals Inc.,
Venkat Jyothsna
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