Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1989-07-20
1991-02-19
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424427, 424435, 424437, 424449, 424473, A61F 1300
Patent
active
049942735
ABSTRACT:
A solubility modulated drug delivery device for controlled release of a therapeutically active ingredient into an environment of use is disclosed. The device comprises a core composition of a solubility modulating agent consisting of a complexing agent or a surfactant and a diffusible, water soluble, therapeutically active agent. The core composition is surrounded by a water insoluble semipermeable wall which is substantially impermeable to the core composition and permeable to the fluids in the environment of use and contains apertures through which active agent is released.
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J. Pharm. Sci. 72, pp. 772-775.
McClelland Gregory A.
Zentner Gaylen M.
DiPrima Joseph F.
Merck & Co. , Inc.
Page Thurman K.
Prater P. L.
Winokur Melvin
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