Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...
Patent
1993-03-31
1996-06-18
Parr, Margaret
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
424181, 424450, 424812, A61K 5112, A61K 9127, A61K 3944
Patent
active
055275281
ABSTRACT:
A method of administering an anti-tumor compound to a subject is disclosed. The method includes administering to a subject liposomes having sizes predominantly in the range 0.05 to 0.12 microns, and containing an anti-tumor compound in liposome-entrapped form, a surface coating of polyethylene glycol chains, at a surface concentration thereof sufficient to extend the blood circulation time of the liposomes severalfold over that of liposomes in the absence of such coating, and surface-attached antibody molecules effective to bind specifically to tumor-associated antigens present at the tumor site. One liposome composition includes doxorubicin in entrapped form, and, on the liposome surface, a monoclonal antibody against highly proliferating cells in a lung squamous cell carcinoma.
REFERENCES:
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 4885172 (1989-12-01), Bally et al.
patent: 4898735 (1990-02-01), Barenholz et al.
patent: 4948590 (1990-08-01), Hawrot et al.
patent: 5013556 (1991-05-01), Woodle et al.
Ding, L., et al., "Effective drug-antibody targeting using a novel monoclonal antibody against the proliferative compartment of mammalian squamous carcinomas" Cancer Immunol. Immunother. 31: 105-109 (1990).
McQuarrie, S. A. et al. , "A Pharmacokinetic Comparison of Murine and Chimeric Forms of the .sup.99m Tc Labelled 174H.64 Monoclonal Antibody,"JNM & Biol.
Hnalowich et al., J. Nucl. Med. 28:1294, 1987, Investigations. . . Applications.
Abuchowski et al. J. Biol. Chem., 252:3582, Effect . . . Catalase, 1977.
Harris et al., TIBTECH, 1993, 11:42, Therapeutic. . . Age.
Zwierzina, Stem Cells, 1993, 11:144. Jansen, J. Biol. Chem. 1991, 266:3343.
Curti, Clin. Rev. Oncol. Hematol., 1993, 14:29. 271:58.
Galli; J. Nucl. Med. all. Sci., 1988, 32:110.
Jain, Sci. Amer, 1994, 271:58.
Allen Theresa M.
Martin Francis J.
Dehlinger Peter J.
Eisenschenk F. Christopher
Mohr Judy M.
Parr Margaret
Sequus Pharmaceuticals, Inc.
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