Solid-supported membrane biosensors

Details Solid-supported membrane biosensors Solid-supported membrane biosensors

1997-02-20

1998-12-08

Warden, Robert J.

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

4352871, 435817, 436525, 436151, 436806, 422 8201, 427 211, 427 213, 204403, C12M 134, G01N 33553, G01N 2726, A61B 5103

Patent

active

058468145

ABSTRACT:
The new membrane biosensors consist of a solid A as a support, a lipid bilayer B as a membrane, spacers C incorporated between A and B and a receptor D embedded in the lipid bilayer. The new membrane biosensors are characterized in particular by their spacer C, which consists of a molecule of ethanolamine which forms an ester bond to the phosphatide group of the lipid bilayer B, an oligopeptide in helical or pleated sheet structure formed from 4-20 C.sub.2 -C.sub.10 -.alpha.-amino acids and a reactive group which enters into a chemical or physicochemical bond with the support A.

REFERENCES:
Lang et al, A New Class of Thiolipids for the Attachment of Lipid Bilayers on Gold Surfaces, American Chemical Society, Langmuir 1994, 10, 197-210.

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