Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-11-08
1998-12-08
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 24, 514 42, 536 41, 536 179, 536 221, 536 291, A61K 3170, C07H 1500
Patent
active
058469435
ABSTRACT:
Disclosed are novel solid support matrices having a toxin-binding oligosaccharide covalently attached to a solid support through a linking arm which has at least 8 atoms separating the oligosaccharide from the solid support. The disclosed solid support matrices are useful for neutralizing toxins from disease-causing microrganisms.
REFERENCES:
patent: 4415733 (1983-11-01), Tayot
patent: 4923980 (1990-05-01), Blomberg
patent: 5079353 (1992-01-01), Ratcliff et al.
patent: 5484773 (1996-01-01), Heereze et al.
Bartlett, J.G., et al., "Antibiotic-Associated Pseudomembranaous Colitis Due to Toxin-Producing Clostridia", N. Engl. J. Med., 298:531-534.
Lyerly, D.M., "Epidemiology of Clostridium difficile Disease", Clin. Microbiol. News 15:49-53, (Apr. 1993).
Heerze, L.D., et al., "Oligosaccharide Sequences Attached to an Inert Support (SYNSORB) as Potential Therapy for Antibiotic-Associated Diarhea and Pseudomembranous Colitis", J. Infect. Dis., 169:1291-1296 (Jun. 1994).
Spangler, B.D., "Structure and Function of Cholera Toxin and Related Escherichia coli Heat-Labile Enterotoxin ", Microbiological Reviews, 56(4):622-647 (Dec. 1992).
Edelman, R, et al., "Summary of the International Symposium and Workshop on Infections Due to Verocytotoxin (Shiga-like Toxin)-Producing Escherichia coli", J. Infect. Dis. 157:1102-1104 (May 1988).
Armstrong, G.D., et al., "Investigation of Shiga-like Toxin Binding to Chemically Synthasized Oligosaccharide Sequences", J. Infect. Dis., 164:1160-1167 (Dec. 1991).
Armstrong, G.D., et al., "A Phase I Study of Chemiclly Synthesized Verotoxin (Shigan-like Toxin) Pk-Trisaccharide Receptors Attached to Chromosorb For Preventing Hemolytic-Uremic Syndrome", J. Infect. Dis., 171:1042-1045 (Apr. 1995).
Karlsson, K.-A., "Animal Glysophingolipids as Membrane Attachment Sites for Bacteria", Ann. Rev. Biochem., 58:309-350 (1989).
Fishman, P.H., "Gangliosides as Reeceptors for Bacterial Enterotoxins", Adv. Lipid Res., 25:165-187 (1993).
Blomberg, L., et al., "Immobilization of Reducing Oligosaccharides to Matrices by a Glycosylamide Linkage", J. Carbohydr. Chem., 12:265-276 (1993).
Hutchins, S.M., et al., "A Stategy for Urea Linked Diamine Libraries", Tetrahedron Letters 36:2583-2586 (1995).
Weetal, et al., "Porous Glass for Affinity Chromatography Applications" in Methods in Enzymology, vol. XXXIV, (Jacoby, et al. Editors), Academic Press, New York (1974) pp. 59-72.
Dubois, et al., "Colorimetric Methods for Determination of Sugars and Related Substances", Anal. Chem., 28:350-356 (Mar. 1956).
Blanken and van de Eijnden, Biosynthesis of Terminal Gal.alpha.1-3Gal.beta.1-4GlcNAc Oligosaccharide Sequences on Glycoconjugates, J. Biol. Chem., 260: 12927-12934 (Oct. 1985).
Palcic, et al., The Use of Hydrophobic Synthetic Glycosides as Acceptors in Glycosyltransferase Assays, Glycoconj. J., 5:49-63 (1988).
Hindsgaul Ole
Nilsson Ulf J.
Fonda Kathleen K.
Synsorb Biotech Inc.
LandOfFree
Solid support matricles containing a toxin binding oligosacchari does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Solid support matricles containing a toxin binding oligosacchari, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solid support matricles containing a toxin binding oligosacchari will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-177331