Stock material or miscellaneous articles – Coated or structually defined flake – particle – cell – strand,... – Particulate matter
Patent
1993-07-12
1995-05-30
Robinson, Douglas W.
Stock material or miscellaneous articles
Coated or structually defined flake, particle, cell, strand,...
Particulate matter
536 253, 548473, 552101, C07D20948, C07H 2104, C07C 1514
Patent
active
054199662
ABSTRACT:
A solid support for oligonucleotide synthesis has the structure ##STR1## where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.
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C. F. Stanfield et al., "Synthesis of Protected Animo Alcohols: A Comparative Study," J. Org. Chem. 46: 4799-4800 (1981).
Meyer, Jr. Rich B.
Petrie Charles R.
Reed Michael W.
Tabone John C.
Kunz Gary
Microprobe Corporation
Robinson Douglas W.
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