Solid-state nuclear magnetic resonance probe

Electricity: measuring and testing – Particle precession resonance – Spectrometer components

Reexamination Certificate

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C324S320000

Reexamination Certificate

active

06937020

ABSTRACT:
A solid-state nuclear magnetic resonance probe that includes multiple sample spinning systems and detection coils is disclosed. The probe can be repositioned within the bore of the magnet to selectively maximize the throughput and sensitivity of the instrument by acquiring a spectrum from one sample at a time while at least one other sample is at or returning to an equilibrium spin state. Methods for the utilization of the probe are also disclosed.

REFERENCES:
patent: 4654592 (1987-03-01), Zens
patent: 5146166 (1992-09-01), Bartuska
patent: 5200702 (1993-04-01), Lilly et al.
patent: 6426058 (2002-07-01), Pines et al.
patent: 6686740 (2004-02-01), Tschirky et al.
patent: 6696838 (2004-02-01), Raftery et al.
patent: 2002/0130661 (2002-09-01), Raftery et al.
“U6 Serial SP6T (Full Size-High Power), DC-12.4 GHz, TYPE N(F) Connectors, Failsafe, Latching, Momentary,”Charter Engineering, Inc, http://www.cciswitchers.com/U6.asp, 6 pgs. (printed Jan. 2, 2003).
Abragam, A., “The Principles Of Nuclear Magnetism,”The International Series of Monographs On Physics, pp. 1-69 (© 1961).
Bennett, A. et al., “Heteronuclear decoupling in rotating solids,”J. Chem. Phys., vol. 103, No. 16, pp. 6951-6958 (Oct. 22, 1995).
Bugay, D., “Review: Solid-State Nuclear Magnetic Resonance Spectroscopy: Theory and Pharmaceutical Applications,”Pharmaceutical Research, vol. 10, No. 3, pp. 317-327 (1993).
Bugay, D., “4: Magnetic Resonance Spectrometry,”Physical Characterization of Pharmaceutical Solids, pp. 93-125 (© 1995).
Byrn, S. et al., “The Crystal Structure, Solid-State NMR Spectra, and Oxygen Reactivity of Five Crystal Forms of Prednisolonetert-Butylacetate,”J. Am. Chem. Soc., vol. 110, pp. 1609-1614 (1988).
Byrn, S. et al., “9: Solid-State NMR Spectroscopy,”Solid-State Chemistry of Drugs, Secod Edition, pp. 119-137 (© 1999).
Chen, L. et al., “Nuclear Magnetic Resonance And Infrared Spectroscopic Analysis Of Nedocromil Hydrates,”Pharm. Res., vol. 17, No. 5, pp. 619-624 (2000).
Dong, Z. et al., “Conformational Flexibility And Hydrogen-Bonding Patterns Of The Neotame Molecular In Its Various Solid Forms,”J. Pharm. Sci., vol. 91, No. 9, pp. 2047-2056 (Sep. 2002).
Dong, Z. et al., “Dehydration Kinetics Of Neotame Monohydratem”J. Pharm. Sci., vol. 91, No. 6, pp. 1423-1431, (Jun. 2002).
Dong, Z. et al., “Neotame Anhydrate Polymorphs I: Preparation And Characterization,”Pharm. Res., vol. 19, No. 3, pp. 330-336 (Mar. 2002).
Dong, Z. et al., “Neotame Anhydrate Polymorphs II: Quantitation and Relative Physical Stability,”Pharm. Res., vol. 19, No. 9, pp. 1259-1264 (Sep. 2002).
Dong, Z. et al., “Crystal Structure of Neotame Anhydrate Polymorph G,”Pharm. Res., vol. 19, No. 10, pp. 1549-1553 (Oct. 2002).
Farrar, C. et al., “High-Frequency Dynamic Nuclear Polarization in the Nuclear Rotating Frame,”Journal of Magnetic Resonance, vol. 144, pp. 134-141 (2000).
Farrar, C. et al., “Mechanism of dynamic nuclear polarization in high magnetic fields,”Journal of Chemical Physics, vol. 114, No. 11, pp. 4922-4933 (Mar. 15, 2001).
Fisher, G. et al., “NMR Probe for the Simultaneous Acquisition of Multiple Samples,”Journal of Magnetic Resonance, vol. 138, pp. 160-163 (1999).
Freeman, R., “Fourier Transformation Free Induction Decay, Intensities, Sensitivity Enhancement, Spin-Lattice Relaxation, Time Averaging,”A Handbook of Nuclear Magnetic Resonance, pp. 80-91, 101-105, 225-229, 250-258, 283-285 (© 1988).
Fukushima, E. et al., “Chapter III Relaxation” and “Chapter IV NMR of Solids,”Experimental Pulse NMR A Nuts and Bolts Approach, pp. 125-295 (© 1981).
Fyfe, C., et al., “Chapters 1, 2, 4, 5, 6,”Solid State NMR For Chemists, pp. 1-31, 139-297 (© 1983).
Harris, R., “6 NMR of the solid state,”Nuclear Magnetic Resonance Spectroscopy, pp. 144-164 (©1983 & 1986).
Hou, T. et al., “NMR analysis of multiple samples using parallel coils: improved performance using reference deconvolution and multidimensional methods,”Analytica Chimica Acta, vol. 400, pp. 297-305 (1999).
Hou, T. et al., “Analysis of Multiple Samples Using Multiplex Sample NMR: Selective Excitation and Chemical Shift Imaging Approaches,”Anal. Chem., vol. 73, pp. 2541-2546 (Jun. 1, 2001).
Kodibagkar, V. et al., “Remote Tuning of NMR Probe Circuits,”Journal of Magnetic Resonance, vol. 144, pp. 53-57 (2000).
Lesage, A. et al., “Determination of Through-Bond Carbon-Carbon Connectivities in Solid-State NMR Using the INADEQUATE Experiment,”J. Am. Chem. Soc., vol. 119, pp. 7867-7868 (1997).
Lesage, A. et al., “Through-Bond Carbon-Carbon Connectivities in Disordered Solids by NMR,”J. Am. Chem., vol. 121, pp. 10987-10993 (1999).
Leung, S. et al., “Hydration and Dehydration Behavior of Aspartame Hemihydrate,”J. Pharm. Sci., vol. 87, No. 4; pp. 508-513 (Apr. 1998).
Leung, S. et al., “Solid-State Characterization of Two Polymorphs of Aspartame Hemihydrate,”J. Pharm. Sci., vol. 87, No. 4, pp. 501-507 (Apr. 1998).
MacNamara, E. et al., “Multiplex sample NMR: an approach to high-throughout NMR using a paralle coil probe,”Analytica Chimica Acta, vol. 397, pp. 9-16 (1999).
MacNamara, E. et al., “Cross Polarization and Cross Relaxation from Laser-Polarized Xenon to Surface Species,”J. Phys. Chem. B, vol. 103, pp. 1158-1160 (1999).
Middleton, D. et al., “A Cross-Polarization Magic-Angle Spinning13C NMR Characterization of the Stable Solid-State Forms of Cimetidine,”Journal of Pharmaceutical Sciences, vol. 86, No. 12, pp. 1400-1402 (Dec. 1997).
Munson, E., “Abstract: In Situ Solid-State Nuclear Magnetic Resonance Studies of Reactions In Zeolite Catalysts,”A Dissertation, 7 pgs. (May 1993).
Offerdahl, T. et al., “Solid-State NMR Spectroscopy of Pharmaceutical Materials,”American Pharmaceutical Review, pp. 1-4 (2003).
Oldfield, E. et al., “A Multiple-Probe Strategy for Ultra-High-Field Nuclear Magnetic Resonance Spectroscopy,”Journal of Magnetic Resonance, Series A, vol. 107, pp. 255-257 (1994).
Padden, B. et al., “Comparison of Solid-State13C NMR Spectroscopy and Powder X-ray Diffraction for Analyzing Mixtures of Polymorphs of Neotame,”Anal. Chem., vol. 71, No. 16, pp. 3325-3331 (Aug. 15, 1999).
Peersen, O. et al., “Variable-Amplitude Cross-Polarization MAS NMR,”Journal of Magnetic Resonance, Series A, vol. 104, pp. 334-339 (1993).
Pines, A. et al., “Proton-enhanced NMR of dilute spins in solids,”The Journal of Chemical Physics, vol. 59, No. 2, pp. 569-590 (Jul. 15, 1973).
Reutzel, S. et al., “Origins of the Unusual Hygroscopicity Observed in LY297802 Tartrate,”Journal of Pharmaceutical Sciences, vol. 87, No. 12, pp. 1568-1571 (Dec. 1998).
Rosay, M. et al., “Two-Dimensional13C-13C Correlation Spectroscopy with Magic Angle Spinning and Dynamic Nuclear Polarization,”J. Am. Chem. Soc., vol. 124, pp. 3214-3215 (2002).
Saindon, P. et al., “Solid-State Nuclear Magnetic Resonance (NMR) Spectra of Pharmaceutical Dosage Forms,”Pharmaceutical Research, vol. 10, No. 2, pp. 197-203 (1993).
Schmidt, W. et al., “Nuclear Magnetic Resonance (NMR) Spectroscopic Investigation of Interaction Energies of Ephedrine Stereoisomers in Noncrystalline Solids and Its Correlation with Thermodynamic Data,”Pharmaceutical Research, vol. 8, No. 9, pp. 1128-1136 (1991).
Serber, Z. et al., “New Carbon-Detected Protein NMR Experiments Using CryoProbes,”J. Am. Chem. Soc., vol. 122, pp. 3554-3555 (2000).
Slichter, C. et al., “5. Spin-Lattice Relaxation and Motional Narrowing of Resonance; Lines, 7. Double Resonance”Principles of Magnetic Resonance, Third Enlarged and Updated Edition, pp. 145-151, 247-295

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