Solid-state form of celecoxib having enhanced bioavailability

Details Solid-state form of celecoxib having enhanced bioavailability Solid-state form of celecoxib having enhanced bioavailability

2007-05-22

2007-05-22

Shameem, Golam M. M. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S356100, C548S373100, C548S376100

Reexamination Certificate

active

11189659

ABSTRACT:
The selective cyclooxygenase-2 inhibitory drug celecoxib is provided in amorphous form. Also provided is a celecoxib drug substance wherein the celecoxib is present, in at least a detectable amount, as amorphous celecoxib. Also provided is a celecoxib-crystallization inhibitor composite comprising particles of amorphous celecoxib or a celecoxib drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such a celecoxib-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous celecoxib, a celecoxib drug substance of the invention, a celecoxib-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention. Also provided is a method of treating a medical condition or disorder in a subject where treatment with a cyclooxygenase-2 inhibitor is indicated, comprising administering, for example orally, a composition of the invention in a therapeutically effective amount.

REFERENCES:
patent: 5466823 (1995-11-01), Talley et al.
patent: 5892053 (1999-04-01), Zhi et al.
patent: 6395300 (2002-05-01), Straub et al.
patent: 6864373 (2005-03-01), Zhuang et al.
patent: 6964978 (2005-11-01), Hageman et al.
patent: WO 00/32189 (2000-07-01), None
patent: WO 00/42021 (2000-07-01), None
ed. S. Budavari, The Merck Index, 12th Edition, Therapeutic Category and Biological Activity Index, (1996), pp. Ther-2 to Ther-3 and Ther-12.
Lieberman et al. (1989), Pharmaceutical Dosage Forms: Tablets, vol. 1, pp. 34-36.

Affiliated with

Also associated with

Rating

Solid-state form of celecoxib having enhanced bioavailability does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Solid-state form of celecoxib having enhanced bioavailability, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solid-state form of celecoxib having enhanced bioavailability will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3738737