Solid solution of an antifungal agent with enhanced bioavailabil

Details Solid solution of an antifungal agent with enhanced bioavailabil Solid solution of an antifungal agent with enhanced bioavailabil

1997-06-25

1999-10-26

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424441, 424464, 424465, 424489, 514770, 5147723, 514784, A61K 914, A61K 920, A61K 948

Patent

active

059723815

ABSTRACT:
A pharmaceutical composition in the form of a substantially amorphous solid solution comprising an antifungal compound of the formula I: ##STR1## wherein: X is F; and R.sub.1 is ##STR2## or an ester or ether of said compound of Formula I; and a soluble or insoluble polymer such as: povidone or crospovidone, wherein the ratio of said compound to said polymer is about 1:3 to about 1:6 is disclosed.

REFERENCES:
patent: 4791111 (1988-12-01), Heeres et al.
Welling, Peter G. Pharmacokinetics, Process and Mathematics, ACS Monograph 185. American Chemical Society, Washington, DC, Chapter 5, p. 57 (1986).

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