Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-02-14
2006-02-14
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S523000
Reexamination Certificate
active
06998398
ABSTRACT:
Pharmaceutically acceptable metal salts of compounds of formula (I):in whichR1is selected from the group consisting of (C1–C6)alkoxy(C1–C6)alkyl which may be substituted with (C1–C6)alkoxy, phenyl-(C1–C6)-alkyl and/or phenyloxy-(C1–C6)-alkyl group in which any phenyl group may be substituted with (C1–C6)alkyl, (C1–C6)alkoxy or halogen, and naphtyl-(C1–C6)-alkyl;R2and R3are each independently hydrogen or halogen;R4is a biolabile ester forming group;and in which the salt is selected from the lithium salt and salts of bivalent metal ions such as magnesium, calcium and zinc. Also described are a method for the preparation of the above salts; pharmaceutical compositions comprising the above salts; methods of using the above salts to treat heart disorders or hypertension, to improve gastrointestinal blood flow, or to treat or inhibit cardiac damage induced by adriamycin and comparable anti-cancer drugs; and crystalline S-α-methylbenzylamine salts of the compounds of formula (I) that are useful as intermediates in production of the above salts.
REFERENCES:
patent: 5783573 (1998-07-01), Rozsa et al.
patent: 0733642 (1996-09-01), None
patent: 0830863 (1998-03-01), None
patent: WO 00/48601 (2000-08-01), None
patent: WO 01/03699 (2001-01-01), None
Zeev B. Alfassi, et al., “Solventing out of Electrolytes form their Aqueous Solution”, AIChE Journal, Sep. 1984, pp. 874-876, vol. 30, No. 5.
Jerzy Mydlarz, et al., “Solubility and Density Isotherms for Potassium Sulfate-Water-2-Propanol”, J. Chem. Eng. Data, 1989, pp. 124-126, 34, American Chemical Society.
J. W. Mullin, et al., “Potassium Sulphate Precipitation from Aqueous Solution by Salting-out with Acetone”, Chem. Eng. Process., 1989, pp .93-99, 26, Elsevier Sequoia, The Netherlands.
de Jong Paulus P. G.
van der Eerden Joris A.
van der Meij Paulus F. C.
Crowell & Moring LLP
Kifle Bruck
Solvay Pharmaceuticals BV
LandOfFree
Solid salts of benzazepine compounds and pharmaceutical... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Solid salts of benzazepine compounds and pharmaceutical..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solid salts of benzazepine compounds and pharmaceutical... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3630806