Solid preparation comprising ion exchanger and active agent

Details Solid preparation comprising ion exchanger and active agent Solid preparation comprising ion exchanger and active agent

1994-04-28

1995-11-07

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

424 7816, 424 7811, 514974, A61K 3174

Patent

active

054646120

ABSTRACT:
(A) A clad powdery or granular preparation of a medicinally active ingredient and (B) a powdery or granular ion exchanger such as a cation exchange resin are blended to prepare a solid preparation. The active ingredient includes .beta.-lactam antibiotics having a basic group. The clad powdery or granular preparation includes not only coated preparation wherein the active ingredient or preparation is coated but also a variety of preparations in which the contact of the active ingredient with the ion exchanger is suppressed or inhibited. Polymers such as a water-soluble polymer, an enteric polymer and so on can be used as the coating agent for the coated preparation. The using amount of the ion exchanger is about 10 to 5,000 parts by weight per 100 parts by weight of the active ingredient. Said solid preparation can remarkably decrease the unpleasant taste and odor of the active ingredient such as bitterness, being excellent in dissolution property and absorbability of the active ingredient.

REFERENCES:
patent: 3954470 (1971-07-01), Borodkin
patent: 4221778 (1980-09-01), Raghunathan
patent: 4762709 (1988-08-01), Sheumaker
patent: 4996047 (1991-02-01), Kelleher et al.
Research Disclosure 17619 Derwent WPI Acc. No. 78-92367 A/51.
Research Disclosure 17620 Derwent WPI Acc. No. 78-92368A/51.

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