Solid phase synthesis with base N alpha-protecting group cleavag

Details Solid phase synthesis with base N alpha-protecting group cleavag Solid phase synthesis with base N alpha-protecting group cleavag

1977-02-01

1978-08-22

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

041088468

ABSTRACT:
An improved solid phase peptide synthesis method is disclosed utilizing base labile N.alpha.-amino acid protecting groups. Such method provides a more efficient synthesis procedure in that it eliminates acid treatment thereby preventing loss of peptide from the support during each deprotection cycle and eliminates a substantial number of wash cycles in each step. A preferred base labile N.alpha.-amino protecting group is the 9-fluorenylmethyloxycarbonyl group (Fmoc) and a preferred base for deprotection is piperidine.

REFERENCES:
patent: 3835175 (1974-09-01), Carpino et al.
patent: 3839396 (1974-10-01), Otsuka et al.
patent: 3944538 (1976-03-01), Bodansky
Merrifield, Advances in Enzymology 32, 1969, pp. 221-295.

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