Solid phase synthesis of protected peptides

Details Solid phase synthesis of protected peptides Solid phase synthesis of protected peptides

1976-12-09

1978-07-18

Hamrock, William F.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Polymers from only ethylenic monomers or processes of...

204 8, 20415912, 2041601, 260 6, 260 7, 260 8, 260515A, 260112R, 260518R, 526 23, 526 46, 526 52, 526 521, C08F 818

Patent

active

041017218

ABSTRACT:
The invention is addressed to the preparation of 3-nitro-4-bromomethyl benzoic acid, as a new compound from which 3-nitro-4-bromomethyl benzoyl amide polystyrene resin can be prepared for solid synthesis of protected peptide acids and amides and separation thereof without cleavage of acid labile protecting groups or decomposition of aromatic acid groups and from which purified polypeptides can be formed.

REFERENCES:
rich et al., "Removal of C-Terminal Peptide . . . Photolysis" Tetrahedron Let'rs., No. 5, pp. 301-304.
Mizoguchi et al., "Solid Phase Peptide Synthesis Employing Aaloacylpolystyrene", Chem. Pharm. Bul. 18, 1465-1474 (1970).
Stewart et al., "Solid Phase Peptide Synthesis" 1969, pp. 1-16.
Sheehan et al., Jour. Org. Chem. 38, (1973) 3771-1774.
Wang, Jour. Polym. Chem., 41, pp. 3258-3261 (1976).

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