Solid phase synthesis of peptides with carboxyl-terminal amides

Details Solid phase synthesis of peptides with carboxyl-terminal amides Solid phase synthesis of peptides with carboxyl-terminal amides

1974-09-06

1976-10-26

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125TR, C07C10352, C07G 700

Patent

active

039883078

ABSTRACT:
The method of utilizing .alpha.,.beta.-unsaturated amino acids, acyl, and N-acyl derivatives as linking agents in the solid phase synthesis of peptides with the corresponding production of carboxyl terminal amides. Preferred unsaturated amino acids are dehydroalanine and dehydrobutyrine which are constituents in naturally occurring amides such as nisin and subtilin. The synthesis follows conventional lines of R. B. Merrifield et al including blocking of the amino nitrogen, with the exception that the release agent contains an amount of water equimolar to the reactant .alpha.,.beta.-unsaturated amino acid.

REFERENCES:
patent: 3732199 (1973-05-01), Schwarz
patent: 3743628 (1973-07-01), Bodanszky et al.
patent: 3775378 (1973-11-01), Dahlmans et al.
patent: 3819607 (1974-06-01), Heuser et al.

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