Solid phase synthesis of peptides

Details Solid phase synthesis of peptides Solid phase synthesis of peptides

1973-02-20

1977-06-07

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

2601125R, 106197R, C08G 6944

Patent

active

040283151

ABSTRACT:
A process for bonding an amino acid to an insoluble hydroxymethyl polymer by esterifying the C-terminal carboxyl group of an N-terminal protected amino acid with the hydroxyl group of an insoluble hydroxymethyl polymer. The esterifying takes place at about room temperature in the presence of a condensing agent. The insoluble hydroxymethyl polymer is a hydroxymethylated copolymer of styrene and divinylbenzene, hydroxymethylcellulose, hydroxymethylated sulfonated polystyrene or polyvinyl alcohol. The condensing agent is dicyclohexylcarbodiimide, carbonyldiimidazole, thionyl chloride, phosphorous oxychloride or ethoxyacetylene. Peptides can be formed by bonding one or more amino acids to the amino acid bonded to the insoluble hydroxymethyl polymer.

REFERENCES:
patent: 3216991 (1965-11-01), Ondetti et al.
patent: 3645996 (1972-02-01), Southarel
patent: 3700609 (1972-10-01), Tregear et al.
Letsinger et al: J. Am. Chem. Soc., 86, 5163-5165 (1964).
Merrifield: J. Am. Chem. Soc., 85, 2149-2154 (1963).
Staab: Chem. Abstr., 53, 16041h (1959).

Affiliated with

Also associated with

Rating

Solid phase synthesis of peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Solid phase synthesis of peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solid phase synthesis of peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1236385