Solid-phase synthesis of oligoribonucleotides

Details Solid-phase synthesis of oligoribonucleotides Solid-phase synthesis of oligoribonucleotides

1997-03-20

1999-02-02

Degen, Nancy

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 241, C07H 2100, C07H 2102, C07H 2104

Patent

active

058667008

ABSTRACT:
A process for the preparation of oligoribonucleotides of the formula ##STR1## in which n, L, BB, W, T, Y', U, C.sup.1 and C.sup.2 are as defined in the description, by solid-phase synthesis is described, as are intermediates of the oligoribonucleotides.

REFERENCES:
patent: 5562358 (1996-10-01), Pfleiderer et al.
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O. Saktsume et al., "Solid Phase Synthesis of Oligoribonucleotides by the Phosphoramidite Approach Using 2'-0-1-(2-chloroethoxy) ethyl Protection." Tetrahedron, vol. 47, No. 41, Oct. 1991, pp. 8717-8728.
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Uhlmann et al., "Antisense Oligonucleotides: A New Therapeutic, . . . " Chemical Reviews, vol. 90, No. 4, 1990, pp. 543-584.

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