Solid phase synthesis of oligonucleotides with stereospecific su

Details Solid phase synthesis of oligonucleotides with stereospecific su Solid phase synthesis of oligonucleotides with stereospecific su

1994-09-02

1997-12-30

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, C07H 100, C07H 2104

Patent

active

057032238

ABSTRACT:
The present invention provides a method for producing an oligonucleotide having stereospecific substituted phosphonate linkages by use of a pentavalent Grignard coupling reaction on a solid phase support. The method can be used for automated synthesis of oligonucleotides having sequential equatorial or axial stereospecific substituted phosphonate linkages.

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patent: 5386023 (1995-01-01), Sanghvi et al.
patent: 5420328 (1995-05-01), Campbell
The 1992 Sigma Chemical Catalog, Sigma Chemical Company, p. 1732.
Stec, et al., "Stereospecific Synthesis of P-Chiral Analogs of Oligonucleotides", Chapter 14 in Methods in Molecular Biology, vol. 20: Protocols for Oligonucleotides and Analogs, S. Agrawal (ed.), Humana Press, Totowa, NJ (1993).
Lesnikowski, et al., Nucleic Acids Research, 16: 11625-11689 (1988).
Bonora, et al., Nucleic Acids Research, 21: 1213-1217 (1993).
Applied Biosystems, Research News, Model 390Z, Feb. 1994.

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