Solid phase synthesis of oligonucleotides

Details Solid phase synthesis of oligonucleotides Solid phase synthesis of oligonucleotides

1997-07-11

1999-08-10

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 253, 935 77, 935 78, C07H 2100, C07H 2102, C07H 2104

Patent

active

059360771

ABSTRACT:
A process is described for preparing oligonucleotides by solid phase synthesis in which exocyclic amino groups present on nucleobases are protected with cyclic diacyl groups, which can be deprotected in the presence of a strong, nonnucleophilic base. Novel intermediates employing the cyclic diacyl protecting groups are also described.

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