Solid phase synthesis of n,n-disubstituted...

Details Solid phase synthesis of n,n-disubstituted... Solid phase synthesis of n,n-disubstituted...

2006-11-21

2006-11-21

Epperson, Jon (Department: 1639)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S389000, C544S388000

Reexamination Certificate

active

07138526

ABSTRACT:
A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

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patent: 9858947 (1998-06-01), None
Sarantakis, D.; Bicksler, J. J. “Solid Phase Synthesis of Sec-Amides and Removal from the Polymeric Support Under Mild Conditions” Tetrahedron Letters. 1997, 38(42), 7325-7328.
Greene, T. H. and Wuts, P. G. M. Protective Groups in Organic Synthesis, 3rd edition, John Wiley & Sons, New York (Apr. 1999), pp. 503-507, 526 and 527.
Kim et al., “Solid phase sythesis of benzamidine and buylamine-derived hydantoin libraries” Molecular Diversity 1998, 3, 129-132.
Generation of a Piperazine-2-Carboxamide Library: A Practical Application of the Phenol-Sulfide React and Release Linker; Breitenbucher et al, Tet. Lett, Mar. 12, 1998, vol. 39, pp. 1295-1298.
Evaluation of a Structure-Based Statine Cyclic Diamino Amide Encoded Combinatorial Library Against Plasmepsin ii and Cathepsin D; Carroll et al, Bioorganic & Medicinal Chem Lett 8, (1998), pp. 3203-3206.

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