Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1997-04-14
1999-09-07
Achutamurthy, Ponnathapura
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436523, 530317, 530328, 530333, 530334, 530335, G01N 33543, A61K 3812
Patent
active
059486937
ABSTRACT:
The present invention relates generally to cyclosporin analogs, and more paritcularly to methods for the solid-phase synthesis and on-resin cyclization of cyclosporin analogs. Methods are described for the on-resin cyclization of sterically hindered compounds synthesized through solid phase synthesis techniques. The methods utilize solvent, temperature, and washing conditions that allow the efficient on-resin cyclization of compounds like analogs of cyclosporin A.
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Angell Yvonne M.
Raman Prakash
Rich Daniel H.
Achutamurthy Ponnathapura
Wisconsin Alumni Research Foundation
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