Solid-phase saccharide sensing compounds

Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Amino acid or sequencing procedure

Reexamination Certificate

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C562S007000

Reexamination Certificate

active

10551032

ABSTRACT:
The present invention provides solid-phase saccharide dyes. The dyes are bisboronic acids covalently bonded to a solid substrate. The dyes selectively conjugate with saccharides, particularly glucose, and register a signal. The signal is proportional to the quantity of saccharide. Thus, the dyes of the present invention are useful for measuring and monitoring saccharide levels, particularly in biological fluids such as blood.

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Linnane et al., A Sweet Toothed Saccharide (PET) Sensor, Tetrahedron Letters, 1995, 36, (48) 8833-8834.
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James et al., A Diboronic Acid ‘Glucose Cleft’ and A Biscrown Ether ‘Metal Sandwich’ are Allosterically Coupled, Journal of the Chemical Society, Chemical Communications, 1995, (14), 1483-1485.

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