Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1974-03-01
1976-08-17
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
23230B, 250303, 424 12, G01N 3300, G01T 116, G21H 502
Patent
active
039755118
ABSTRACT:
Method of determining the concentration of a substance in a solution which comprises the steps of incubating the solution with a known amount of radioactively labelled substance and a suspendable composite consisting of anti-substance antibody coupled chemically through an intermediate silane coupling agent to an inorganic carrier, the incubation period being for a time sufficient to form immunochemical complexes, separating the complexes from the solution, determining the radioactivity of either the separated complexes or the remaining solution, and relating that determination to a standard curve. Specific assays for digoxin, insulin, and estriol are disclosed.
REFERENCES:
patent: 3519538 (1970-07-01), Messing et al.
patent: 3652761 (1972-03-01), Woetall
patent: 3669841 (1972-06-01), Miller
Vann William P.
Yaverbaum Sidney
Corning Glass Works
Giblin James A.
Janes Jr. Clinton S.
Nucker Christine M.
Padgett Benjamin R.
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