Solid phase preparation of 18 F-labelled amino acids

Details Solid phase preparation of 18 F-labelled amino acids Solid phase preparation of 18 F-labelled amino acids

2007-09-04

2007-09-04

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C534S011000

Reexamination Certificate

active

10539165

ABSTRACT:
A process for the production of an18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O-TRACER (I) with18F— to produce the labelled tracer of formula (II)

REFERENCES:
patent: 5808146 (1998-09-01), Goodman
patent: 97/17092 (1997-05-01), None
patent: WO 03/002157 (2003-01-01), None
Chemical Abstract AN 1988:130967 of J. of Labelled Compounds and Radiopharm. (1987), vol. 24(9), pp. 1029-1042.
Martarello—Journal of Medicinal Chemistry (2002), vol. 45, pp. 2250-2259, in particular scheme 3.
Shoup—Journal of labeled Compounds and Radiopharmaceuticals (1999), vol. 42, pp. 215-225, in particular the final step in fig. 1.
Shoup—Journal of Nuclear Med., vol. 40, No. 2, 1999, pp. 331-338.
Search Report of GB 0229695.2 dated May 30, 2003.
Int'l Search Report for PCT/GB2003/005576 dated May 3, 2004.
Int'l Preliminary Exam Report for PCT/GB2003/005576 dated Sep. 27, 2004.

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