Solid-phase preparation of [ 18 F] fluorohaloalkanes

Details Solid-phase preparation of [ 18 F] fluorohaloalkanes Solid-phase preparation of [ 18 F] fluorohaloalkanes

2007-05-29

2007-05-29

Barts, Samuel A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Halogen containing

C570S106000

Reexamination Certificate

active

10539163

ABSTRACT:
The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX (I) wherein n is an integer of from (1) to (7) and X is chloro, bromo or iodo; with18F−to produce the [18F]fluorohaloalkane of formula (II)18F—(CH2)n—X (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess18F−, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

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S. Comagic, M. Piel, R. Schirrmacher, S Hohnemann, F. Rosch Applied Research and Isotopes 56 (2002) 847-851.
Chemical Abstract AN 1988:130967 of J. of Labelled Compounds and Radiopharm. (1987), vol. 24(9), pp. 1029-1042.
S. Comagic, et al., “Efficient Synthesis of 2-Bromor1- 18F-fluorethane and its Applicationin the Automated Preparation of 18F-Fluorethlated Compounds” Applied radiation and isotopes, vol. 56, 2002, pp. 847-851.
Search Report for GB 0229688.7 dated May 29, 2003.
Int'l Search report for PCT/GB2003/005630 dated May 4, 2004.
Int'l Preliminary Examination Report for PCT/GB2003/005630 dated Oct. 21, 2004.

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