Solid phase peptide synthesizer

Details Solid phase peptide synthesizer Solid phase peptide synthesizer

1994-12-29

1995-09-26

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

C07K 104

Patent

active

054534879

ABSTRACT:
The invention provides methods and apparatuses for solid-phase peptide synthesis which employ solvent/reagent delivery and measuring systems open to atmospheric pressure coupled to pressurized transfer and reaction systems. The delivery and measuring systems consists of multiple solvent vessels connected to a metering vessel through individual, uninterrupted solvent lines. The metering vessel is connected to a transfer vessel by a valve through which solvent is gravity fed to the transfer vessel. The solvent is now in a closed, single pathway system and can be pressurized from the transfer vessel to a reaction vessel. This closed system allows the complete inversion of the reaction vessel; with the advantage of guaranteeing complete resin to solvent contact without any possibility of loss of resin product. All of the steps are accomplished by the opening and closing of individual valves that are controlled through a personal computer and system software that allow the user to do these steps individually or in any combination and length.

REFERENCES:
patent: 3557077 (1971-01-01), Brunfeldt et al.
patent: 3647390 (1972-03-01), Kubodera et al.
patent: 3715190 (1973-02-01), Park et al.
patent: 4362699 (1982-12-01), Verlander et al.
patent: 4668476 (1987-05-01), Bridgham et al.
patent: 4746490 (1988-05-01), Saneii
patent: 4748002 (1988-05-01), Neimark et al.
patent: 4800166 (1989-01-01), Horn et al.
patent: 4816513 (1989-03-01), Bridgham et al.
patent: 4861866 (1989-08-01), Durrum et al.
patent: 5026773 (1991-06-01), Steel
patent: 5053454 (1991-10-01), Judd
patent: 5186898 (1993-02-01), Bridgham et al.
patent: 5223435 (1993-06-01), Kohr
patent: 5240680 (1993-08-01), Zuckerman et al.
patent: 5380495 (1995-01-01), Chang et al.
Stewart et al., "Solid Phase Peptide Synthesis", 2nd ed., published 1984 by Pierce Chemical Co., (Rockford, Ill.), pp. 130-133.

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