Solid phase peptide synthesis using a polyacrylic support in aqu

Details Solid phase peptide synthesis using a polyacrylic support in aqu Solid phase peptide synthesis using a polyacrylic support in aqu

1991-09-26

1992-12-29

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, A61K 3702, C07K 500

Patent

active

051752549

ABSTRACT:
This invention relates to solid phase peptide synthesis.
Solid phase peptide synthesis is accomplished on polyacrylic resins (such as those described in EP 0 079 812 and EP 0 081 408 which correspond to U.S. Pat. Nos. 4,436,874 and 4,439,545 respectively) by a method which includes in the coupling protocol steps of washing the resin in water and/or aqueous solution(s).

REFERENCES:
patent: 4436874 (1984-03-01), Aspisi et al.
Calas et al. "Solid Phase Syntheses Using a New Polyacrylic Resin", 41 Tetrahedron No. 22 pp. 5331-5339 (1985).
Atherton et al. "Peptide Syntheses . . . " J. Chem. Soc. Perkin Transaction I, 538-545 (1981).
Arshady et al. "Peptide Syntheses . . . " J. Chem. Soc. Perkin Trans I, 529-537 (1981).

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