Solid phase oligonucleotide synthesis using phospholane intermed

Details Solid phase oligonucleotide synthesis using phospholane intermed Solid phase oligonucleotide synthesis using phospholane intermed

1992-01-23

1996-04-30

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2671, 536 2680, 536 2690, C07H 2102, C07H 2104

Patent

active

055126685

ABSTRACT:
Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O- 1,3,2-dichalcogen-substituted-phospholane! synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O- 1,3,2-dichalcogen-substituted-phospholane! synthons, and P-chiral oligonucleotides and related P-chiral polymers.

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