Solid phase native chemical ligation of unprotected or...

Details Solid phase native chemical ligation of unprotected or... Solid phase native chemical ligation of unprotected or...

2006-08-22

2006-08-22

Gupta, Anish (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

C530S326000, C530S333000, C530S339000, C530S350000, C530S402000, C435S283100, C525S054100

Reexamination Certificate

active

07094871

ABSTRACT:
The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueous solution. Also provided are methods of monitoring solid phase sequential ligation reactions using MALDI or electrospray ionization mass spectrometry of reaction products.

REFERENCES:
patent: 6326468 (2001-12-01), Canne et al.
patent: WO 96/34878 (1996-11-01), None
patent: WO 98/28434 (1998-07-01), None
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